Background: Time-restricted eating (TRE), without calorie counting, has become a popular weight loss strategy, yet long-term randomized trials evaluating its efficacy are limited. Objective: To determine whether TRE is more effective for weight control and cardiometabolic risk reduction compared with calorie restriction (CR) or control. Design: 12-month randomized controlled trial. (ClinicalTrials.gov: NCT04692532) Setting: University of Illinois Chicago from January 2021 to September 2022. Participants: 90 adults with obesity. Intervention: 8-hour TRE (eating between noon and 8:00 p.m. only, without calorie counting), CR (25% energy restriction daily), or control (eating over a period of 10 or more hours per day). Participants were not blinded. Measurements: Change in body weight, metabolic markers, and energy intake by month 12. Results: Seventy-seven persons completed the study. Mean age was 40 years (SD, 11), 33% were Black, and 46% were Hispanic. Mean reduction in energy intake was −425 kcal/d (SD, 531) for…