Взрослые Herpes zoster (shingles), treatment: Note: Initiate at earliest sign or symptom. Antiviral treatment is most effective ≤72 hours after rash onset but may be initiated >72 hours in certain situations (eg, new lesions continue to appear); for immunocompromised patients, initiate treatment even if >72 hours after symptom onset unless all lesions have crusted (Ref). Acute localized dermatomal lesion(s): Oral: 1 g 3 times daily for 7 to 10 days; for slowly improving lesions, may extend therapy until resolution (Ref). For select immunocompromised patients at high risk of dissemination (eg, recent transplant, graft-versus-host disease), some experts suggest regimens used for disseminated zoster (Ref). Disseminated zoster (extensive cutaneous lesions or visceral involvement): Oral: Initial therapy with acyclovir IV may be switched to valacyclovir 1 g 3 times daily to complete a 10- to 14-day course when formation of new lesions has ceased and signs/symptoms of visceral infection are improving (Ref).