How long does it take for a sperm to travel to an egg? When can you open the champagne and rejoice at a successful fertilization? Joke😁 From the moment of ejaculation, when the spermatozoa penetrate the uterine cavity, only half an hour to an hour passes. And it takes them an hour and a half to two hours to penetrate the widest part, which is called the ampulla. That's a total of two to three hours.