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Circadian rhythms play a role in regulating sleep, hormone production, body temperature
They set the right tempo for the brain to work. The invention of the electric lamp a century and a half ago had a fatal effect on sleep mechanisms, people began to sleep significantly less than their biological essence requires, and this leads to numerous negative consequences - circadian rhythm malfunctions, various kinds of depression and other pathologies.
To imagine the effect that this disruption produces on the unaware hypothalamus, it is enough to take an intercontinental flight with a large time difference.