Is it possible for the heart to ache from excessive emotion? Undoubtedly, yes. Excitement causes the heart to beat faster and the blood pressure to rise. In people with impaired oxygen supply to the heart, this will cause pain in the heart area. There’s also a disease in which the heart responds inadequately to emotional distress, while the vessels feeding it are normal. Call it Takotsubo cardiomyopathy or "Broken Heart Syndrome".