What is ischemia and where does it lead to? The condition is a serious threat to any tissue. Ischemia is a decrease in the amount of blood flow to an organ. This leads to a "shortage" of nutrients and oxygen deprivation. When this deficiency occurs, organ function deteriorates and ischemia can result in cell death (like a heart attack or stroke). The two main causes of ischemia are vascular atherosclerosis (first in the animation) and vasoconstriction (second in the animation) Our NFT channel